Probably benign lesions at breast magnetic resonance imaging: Preliminary experience in high-risk women Journal Article

Authors: Liberman, L.; Morris, E. A.; Benton, C.; Abramson, A. F.; Dershaw, D
Article Title: Probably benign lesions at breast magnetic resonance imaging: Preliminary experience in high-risk women
Abstract: BACKGROUND. The purpose of the current study was to determine the frequency of 'probably benign' interpretations at breast magnetic resonance (MR) imaging screening of high-risk women and the frequency of subsequent malignancy in these women. METHODS. The authors performed a retrospective review of the records of 367 asymptomatic women with normal mammograms who had a high risk of developing breast cancer and whose first breast MR imaging screening examinations occurred during a 2-year period. The number of "probably benign" interpretations was determined, and follow-up data were obtained. RESULTS. A "probably benign" interpretation was given to 89 (24%) of 367 women. Follow-up MR imaging was performed for 70 (79%) of 89 women, with a median follow-up time of 11 months (range, 1-24 months). Twenty women subsequently underwent biopsy at a median of 9 months (range, 1-18 months) after MR imaging, due to progression on follow-up MR imaging (n = 14) or for other reasons (n = 6). Malignancies were found in 9 women, constituting 45% of the 20 women who underwent biopsy and 10% of the 89 women with probably benign lesions. In 6 of the 9 women who developed malignant disease (7% of the 89 women in the study), the malignancy was detected by follow-up MR imaging of an area that previously was interpreted as probably benign. Tumor histology was ductal carcinoma in situ (DCIS) in five patients and infiltrating ductal carcinoma in four. CONCLUSIONS. A "probably benign" interpretation was given to 24% of high-risk women at their first breast MR imaging screening examination. In 7-10% of women with "probably benign" interpretations, malignant disease subsequently developed in an area initially judged to be probably benign; of these malignancies, more than half were DCIS, and more than half were detected by MR imaging only. © 2003 American Cancer Society.
Keywords: adult; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; histopathology; cancer risk; cancer patient; nuclear magnetic resonance imaging; follow up; magnetic resonance imaging; cancer diagnosis; diagnosis, differential; breast; risk factors; cancer screening; diagnostic imaging; breast neoplasms; mammography; screening; breast tumor; breast carcinoma; carcinoma in situ; predictive value of tests; high risk population; breast biopsy; breast lesion; follow-up; humans; human; female; priority journal; article
Journal Title: Cancer
Volume: 98
Issue: 2
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2003-07-15
Start Page: 377
End Page: 388
Language: English
DOI: 10.1002/cncr.11491
PUBMED: 12872360
PROVIDER: scopus
Notes: Export Date: 12 September 2014 -- Source: Scopus
Citation Impact
MSK Authors
  1. D David Dershaw
    203 Dershaw
  2. Laura Liberman
    172 Liberman
  3. Elizabeth A Morris
    295 Morris
  4. Catherine   Benton
    2 Benton