New retinoblastoma tumor formation in children initially treated with systemic carboplatin Journal Article
| Authors: | Lee, T. C.; Hayashi, N. I.; Dunkel, I. J.; Beaverson, K.; Novetsky, D.; Abramson, D. H. |
| Article Title: | New retinoblastoma tumor formation in children initially treated with systemic carboplatin |
| Abstract: | Purpose: To determine the frequency and timing of new intraocular tumor formation in children with hereditary retinoblastoma initially treated with systemic carboplatin. Design: Retrospective, noncomparative case series. Participants: This study included 34 children (57 eyes) with hereditary bilateral retinoblastoma initially treated with systemic carboplatin at the Robert M. Ellsworth Ophthalmic Oncology Center at New York-Presbyterian Hospital from 1994 through 2000. Main Outcome Measures: New tumor formation after initial treatment with systemic carboplatin. Results: There were a total of 165 tumors in 57 eyes. There were 63 new tumors in 27 eyes (47%) after administration of systemic carboplatin, for a mean of 1.1 new tumors per eye. The mean patient age at time of new tumor presentation was 9 months, with 57% of new tumors developing within 4 months of carboplatin treatment. Kaplan-Meier analysis showed that children who were treated when younger than 6 months of age were more likely to have new tumors (60%) compared with those treated after 6 months of age (31%; P = 0.0182). Conclusions: New intraocular tumors continue to develop after systemic carboplatin; most new tumors appeared within 4 months of treatment. © 2003 by the American Academy of Ophthalmology. |
| Keywords: | cancer chemotherapy; clinical article; preschool child; treatment outcome; child, preschool; retrospective studies; cancer recurrence; antineoplastic agents; united states; follow up; heredity; carboplatin; risk factors; retinoblastoma; retinal neoplasms; retrospective study; time factors; carcinogenesis; iodine 125; infant; infant, newborn; newborn; enucleation; age distribution; neoplasms, second primary; kaplan meier method; humans; human; male; female; priority journal; article |
| Journal Title: | Ophthalmology |
| Volume: | 110 |
| Issue: | 10 |
| ISSN: | 0161-6420 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-10-01 |
| Start Page: | 1989 |
| End Page: | 1994 |
| Language: | English |
| DOI: | 10.1016/s0161-6420(03)00669-9 |
| PUBMED: | 14522776 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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