Vesicant characteristics of oxapliplatin following antecubital extravasation Journal Article
| Authors: | Kennedy, J. G.; Donahue, J. P.; Hoang, B.; Boland, P. J. |
| Article Title: | Vesicant characteristics of oxapliplatin following antecubital extravasation |
| Abstract: | Oxaliplatin is a novel class of platinum chermotherapeutic agent used in refractory adenocarcinoma. It has previously been regarded as a non-vesicant, and as such was considered safe to administer through peripheral veins. This report documents severe muscle and subcutaneous reaction with a single dose of oxaliplatin at the site of extravasation in a patient aged 58 years. Conventional therapeutic modalities were employed to reduce the effect of the soft tissue infiltrate. Despite that, significant muscle necrosis and fibrosis occurred. Surgery was deferred secondary to patient choice, and eventual extensive physical therapy restored function to the elbow joint. This case shows that oxaliplatin may not be an appropriate cytotoxic agent to be administered through a peripheral line and consideration must be made for central access when this drug is used. In addition, when extravasation does occur, the current report indicates that non-surgical management can be successful. © 2003 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
| Keywords: | adult; middle aged; cancer surgery; unclassified drug; case report; cisplatin; fluorouracil; drug potentiation; drug safety; antineoplastic agents; paclitaxel; antineoplastic agent; adenocarcinoma; liver toxicity; nephrotoxicity; irinotecan; celecoxib; folinic acid; elbow; platinum; muscle disease; vinca alkaloid; medical documentation; platinum complex; sensory dysfunction; vancomycin; mitomycin; anthracycline; oxaliplatin; rectum carcinoma; decision making; rectal neoplasms; rectum tumor; organoplatinum compounds; physiotherapy; soft tissue disease; subcutaneous tissue; extravasation; myofibrosis; drug extravasation; irritant agent; contrast medium extravasation; irritants; sodium thiosulfate; joint function; extravasation of diagnostic and therapeutic materials; humans; human; female; priority journal; article; sulfoxide; fluorouracil calcium; fluorouracil derivative; auditory system function; muscle necrosis; soft tissue injury |
| Journal Title: | Clinical Oncology |
| Volume: | 15 |
| Issue: | 5 |
| ISSN: | 0936-6555 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-08-01 |
| Start Page: | 237 |
| End Page: | 239 |
| Language: | English |
| DOI: | 10.1016/s0936-6555(02)00338-2 |
| PUBMED: | 12924452 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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