A multigenic program mediating breast cancer metastasis to bone Journal Article
| Authors: | Kang, Y.; Siegel, P. M.; Shu, W.; Drobnjak, M.; Kakonen, S. M.; Cordón-Cardo, C.; Guise, T. A.; Massagué, J. |
| Article Title: | A multigenic program mediating breast cancer metastasis to bone |
| Abstract: | We investigated the molecular basis for osteolytic bone metastasis by selecting human breast cancer cell line subpopulations with elevated metastatic activity and functionally validating genes that are overexpressed in these cells. These genes act cooperatively to cause osteolytic metastasis, and most of them encode secreted and cell surface proteins. Two of these genes, interleukin-11 and CTGF, encode osteolytic and angiogenic factors whose expression is further increased by the prometastatic cytokine TGFβ. Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor. |
| Keywords: | controlled study; protein expression; bone neoplasms; intercellular signaling peptides and proteins; osteolysis; human cell; nonhuman; bone metastasis; mouse; animals; mice; animal tissue; gene overexpression; breast cancer; gene expression; gene expression profiling; transforming growth factor beta; neoplasm proteins; animal experiment; animal model; cancer cell culture; tumor cells, cultured; breast neoplasms; mice, inbred balb c; animalia; gene expression regulation, neoplastic; cytokine; mice, nude; oligonucleotide array sequence analysis; chromatin; nucleotide sequence; cell subpopulation; neoplasm invasiveness; nucleic acid hybridization; molecular biology; immediate-early proteins; genetic code; connective tissue growth factor; multigene family; angiogenic factor; mitogens; insulin-like growth factor binding proteins; interleukin-11; interleukin 11; precipitin tests; humans; prognosis; human; female; priority journal; article |
| Journal Title: | Cancer Cell |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2003-06-01 |
| Start Page: | 537 |
| End Page: | 549 |
| Language: | English |
| DOI: | 10.1016/s1535-6108(03)00132-6 |
| PUBMED: | 12842083 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Molecular Sequence Numbers: GENBANK: AF052162, AL080059, AL137718, FLJ11190, LOC51203, LOC57110; -- Source: Scopus |
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