Resection of locally recurrent colorectal cancer in the presence of distant metastases: Can it be justified? Journal Article
| Authors: | Hartley, J. E.; Lopez, R. A.; Paty, P. B.; Wong, W. D.; Cohen, A. M.; Guillem, J. G. |
| Article Title: | Resection of locally recurrent colorectal cancer in the presence of distant metastases: Can it be justified? |
| Abstract: | Background: We aimed to determine the outcome of resections for local recurrence of colorectal carcinoma in the presence of distant (M1) disease. Methods: Patients who underwent resection of local recurrence in the presence of potentially resectable M1 disease were identified from the colorectal database. Outcome was determined by chart review. Results: Forty-two patients (23 men) of mean age 60 years (range, 34-88 years) underwent complete gross resection of their local recurrence in the presence of M1 disease. Thirteen of the 42 underwent synchronous M1 resections to render them free of gross disease (R0). Nine of the 29 patients who left with residual disease (R1) subsequently underwent staged M1 resection, so that 22 of 42 were rendered R0 by surgery. The median survival of all patients was 14.5 months (interquartile range, 6-30 months), and that of patients rendered R0 was 23 months (interquartile range, 10-37 months), in comparison with 7 months (interquartile range, 3-25 months) for those of R1 status (P = .006; log-rank method). Ability to achieve R0 status by synchronous or staged resection was the only factor predictive of survival. Conclusions: The presence of M1 disease per se should not preclude resection of local recurrence, although case selection is problematic. © 2003 The Society of Surgical Oncology, Inc. |
| Keywords: | survival; adult; cancer survival; clinical article; controlled study; treatment outcome; aged; aged, 80 and over; middle aged; cancer surgery; cancer recurrence; cancer staging; follow up; follow-up studies; neoplasm staging; colorectal cancer; metastasis; neoplasm recurrence, local; pathology; data base; prediction; distant metastasis; colorectal neoplasms; liver metastasis; lung metastasis; colorectal tumor; tumor recurrence; neoplasm metastasis; resection; factual database; databases, factual; local recurrence; humans; prognosis; human; male; female; article |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 10 |
| Issue: | 3 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2003-04-01 |
| Start Page: | 227 |
| End Page: | 233 |
| Language: | English |
| DOI: | 10.1245/aso.2003.05.039 |
| PUBMED: | 12679306 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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