Tumor promotion by Mdm2 splice variants unable to bind p53 Journal Article
| Authors: | Fridman, J. S.; Hernando, E.; Hemann, M. T.; de Stanchina, E.; Cordon-Cardo, C.; Lowe, S. W. |
| Article Title: | Tumor promotion by Mdm2 splice variants unable to bind p53 |
| Abstract: | The Mdm2 oncoprotein physically associates with p53 and antagonizes its tumor suppressor functions. Previous studies indicate that some tumors express alternatively or aberrantly spliced Mdm2 variants that are unable to bind p53, but whether these actively contribute to carcinogenesis or are a byproduct of cancer progression has been unclear. In this study, we examined the ability of full-length Mdm2 and several tumor-derived splice variants to modulate tumor development in Eμ-myc transgenic mice. We report that several tumor-derived Mdm2 splice variants promote tumorigenesis in a manner that is comparable with full-length Mdm2. Our results imply that the current paradigm for understanding Mdm2 action during oncogenesis is incomplete, and its splice variants contribute to human cancer. |
| Keywords: | controlled study; protein expression; oncoprotein; proto-oncogene proteins; cancer growth; nonhuman; animal cell; mouse; animals; mice; protein protein interaction; animal experiment; animal model; protein binding; protein p53; mice, inbred c57bl; carcinogenesis; transgenic mouse; mice, transgenic; nuclear proteins; lymphoma, b-cell; alternative splicing; tumor suppressor protein p53; tumor growth; protein isoforms; oncogene myc; protein mdm2; proto-oncogene proteins c-mdm2; dna, complementary; humans; priority journal; article |
| Journal Title: | Cancer Research |
| Volume: | 63 |
| Issue: | 18 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2003-09-15 |
| Start Page: | 5703 |
| End Page: | 5706 |
| Language: | English |
| PUBMED: | 14522887 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
