Application of the logic of cysteine-free native chemical ligation to the synthesis of Human Parathyroid Hormone (hPTH) Journal Article
| Authors: | Shang, S.; Tan, Z.; Danishefsky, S. J. |
| Article Title: | Application of the logic of cysteine-free native chemical ligation to the synthesis of Human Parathyroid Hormone (hPTH) |
| Abstract: | The power of chemical synthesis of large cysteine-free polypeptides has been significantly enhanced through the use of nonproteogenic constructs which bear strategically placed thiol groups, enabling native chemical ligation. Central to these much expanded capabilities is the specific, radical-induced, metal-free dethiolation, which can be accomplished in aqueous medium. |
| Keywords: | conference paper; peptide; parathyroid hormone; desulfurization; hormone synthesis; chemical modification; polypeptide; alanine ligation; leucine ligation; valine ligation; thiol derivative; cysteine free native chemical ligation |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 108 |
| Issue: | 15 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2011-04-12 |
| Start Page: | 5986 |
| End Page: | 5989 |
| Language: | English |
| DOI: | 10.1073/pnas.1103118108 |
| PROVIDER: | scopus |
| PMCID: | PMC3076867 |
| PUBMED: | 21444787 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: PNASA" - "Source: Scopus" |
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