Effects of therapy on dentofacial development in long-term survivors of head and neck rhabdomyosarcoma: The Memorial Sloan-Kettering Cancer Center experience Journal Article

  

Authors:	Estilo, C. L.; Huryn, J. M.; Kraus, D. H.; Sklar, C. A.; Wexler, L. H.; Wolden, S. L.; Zlotolow, I. M.
Article Title:	Effects of therapy on dentofacial development in long-term survivors of head and neck rhabdomyosarcoma: The Memorial Sloan-Kettering Cancer Center experience
Abstract:	Purpose: To describe potential effects of multimodality therapy on dental and facial development in long-term survivors of head and neck rhabdomyosarcoma. Patients and Methods: The medical records of all patients aged 20 years or less presenting between 1985 and 1996 with a diagnosis of rhabdomyosarcoma and treated by protocol were reviewed. Head and neck rhabdomyosarcoma patients who were followed in the Dental Service and were alive and free of disease with at least a 5-year follow-up were included in the review. Ten patients satisfied the inclusion criteria and form the basis of this report. The median age at diagnosis of the 10 patients was 4.3 years (range 10 months to 19.5 years). All patients were treated with chemotherapy, two patients underwent surgery, and all but one patient received external beam radiation therapy. Results: Clinical or radiographic dentofacial abnormalities were observed in 8 of the 10 (80%) patients. Abnormalities included enamel defects, bony hypoplasia/facial asymmetry, trismus, velopharyngeal incompetency, tooth/root agenesis, and disturbance in root development. Bony hypoplasia and disturbance in root formation were the most common findings. Conclusions: Multimodality therapy for head and neck rhabdomyosarcoma can result in dentofacial abnormalities that affect the patient's quality of life. The care of the long-term survivor requires a multidisciplinary approach, including early involvement of the dental team.
Keywords:	adolescent; adult; cancer survival; child; clinical article; child, preschool; excision; cisplatin; doxorubicin; multimodality cancer therapy; antineoplastic agents; combined modality therapy; methotrexate; follow up; antineoplastic agent; quality of life; etoposide; radiotherapy; cyclophosphamide; vincristine; ifosfamide; survivors; cancer center; infant; head and neck cancer; head and neck neoplasms; medical record; dactinomycin; rhabdomyosarcoma; trismus; hypodontia; tooth development; tooth diseases; abnormalities; multimodality therapy; face development; tooth; beam therapy; palatopharyngeal incompetence; hypoplasia; humans; human; male; female; priority journal; article; dentofacial; face asymmetry; tooth radiography; maxillofacial development
Journal Title:	Journal of Pediatric Hematology/Oncology
Volume:	25
Issue:	3
ISSN:	1077-4114
Publisher:	Lippincott Williams & Wilkins
Date Published:	2003-03-01
Start Page:	215
End Page:	222
Language:	English
DOI:	10.1097/00043426-200303000-00007
PUBMED:	12621240
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0037336193&partnerID=40&md5=097da96026e5ca6ffc7031605de2f641
Notes:	Export Date: 12 September 2014 -- Source: Scopus

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