Resistance to enediyne antitumor antibiotics by CalC self-sacrifice Journal Article
| Authors: | Biggins, J. B.; Onwueme, K. C.; Thorson, J. S. |
| Article Title: | Resistance to enediyne antitumor antibiotics by CalC self-sacrifice |
| Abstract: | Antibiotic self-resistance mechanisms, which include drug elimination, drug modification, target modification, and drug sequestration, contribute substantially to the growing problem of antibiotic resistance among pathogenic bacteria. Enediynes are among the most potent naturally occurring antibiotics, yet the mechanism of resistance to these toxins has remained a mystery. We characterize an enediyne self-resistance protein that reveals a self-sacrificing paradigm for resistance to highly reactive antibiotics, and thus another opportunity for nonpathogenic or pathogenic bacteria to evade extremely potent small molecules. |
| Keywords: | controlled study; unclassified drug; nonhuman; gene; drug resistance; pathology; structure-activity relationship; bacteria (microorganisms); antibiotic resistance; anti-bacterial agents; bacterial proteins; drug resistance, bacterial; dna; drug distribution; drug mechanism; tumors; escherichia coli; immunoassay; antibiotics, antineoplastic; antineoplastic antibiotic; bacterium; polyacrylamide gel electrophoresis; chemical modification; drug elimination; antibiotics; agar gel electrophoresis; bacteria; aminoglycosides; metalloproteins; drug transformation; enediynes; priority journal; article; alkenyldialkyne derivative; calicheamicin gamma1; dyemicin; esperamicin; namenamicin; shishijimicin a; calicheamicin c gene |
| Journal Title: | Science |
| Volume: | 301 |
| Issue: | 5639 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2003-09-12 |
| Start Page: | 1537 |
| End Page: | 1541 |
| Language: | English |
| DOI: | 10.1126/science.1086695 |
| PUBMED: | 12970566 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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