Shifting the equilibrium in cancer immunoediting: From tumor tolerance to eradication Journal Article
| Authors: | Quezada, S. A.; Peggs, K. S.; Simpson, T. R.; Allison, J. P. |
| Article Title: | Shifting the equilibrium in cancer immunoediting: From tumor tolerance to eradication |
| Abstract: | The continual interaction of the immune system with a developing tumor is thought to result in the establishment of a dynamic state of equilibrium. This equilibrium depends on the balance between effector and regulatory T-cell compartments. Whereas regulatory T cells can infiltrate and accumulate within tumors, effector T cells fail to efficiently do so. Furthermore, effector T cells that do infiltrate the tumor become tightly controlled by different regulatory cellular subsets and inhibitory molecules. The outcome of this balance is critical to survival, and whereas in some cases the equilibrium can rapidly result in the elimination of the transformed cells by the immune system, in many other cases the tumor manages to escape immune control. In this review, we discuss relevant work focusing on the establishment of the intratumor balance, the dynamic changes in the populations of effector and regulatory T cells within the tumor, and the role of the tumor vasculature and its activation state in the recruitment of different T-cell subsets. Finally, we also discuss work associated to the manipulation of the immune response to tumors and its impact on the infiltration, accumulation, and function of tumor-reactive lymphocytes within the tumor microenvironment. © 2011 John Wiley & Sons A/S. |
| Keywords: | protein expression; unclassified drug; overall survival; review; cancer growth; nonhuman; pancreas cancer; transcription factor foxp3; cd8+ t lymphocyte; cell survival; cell compartmentalization; cell function; cytotoxic t lymphocyte antigen 4 antibody; glycoprotein gp 100; melanoma; immune system; transforming growth factor beta; vascular cell adhesion molecule 1; cyclophosphamide; monoclonal antibody; t lymphocyte receptor; immunological tolerance; regulatory t lymphocyte; immune response; immunotherapy; cell transformation; immunogenicity; cd4+ t lymphocyte; cytotoxic t lymphocyte; ovary carcinoma; cell therapy; tumor immunity; cytokine production; effector cell; cancer control; peptide vaccine; lymphocytic infiltration; cytotoxic t lymphocyte antigen 4; granulocyte macrophage colony stimulating factor vaccine; t cell depletion; cytokine release; immunosurveillance; tumor vascularization; lymphocyte; intercellular adhesion molecule 1; t lymphocyte subpopulation; t lymphocyte activation; apc protein; cd28 antigen; lewis carcinoma; vaccines; helper cell; costimulation; tumor microenvironment; ipilumimab; ox 40; body equilibrium; cancer immunoediting |
| Journal Title: | Immunological Reviews |
| Volume: | 241 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2011-05-01 |
| Start Page: | 104 |
| End Page: | 118 |
| Language: | English |
| DOI: | 10.1111/j.1600-065X.2011.01007.x |
| PROVIDER: | scopus |
| PUBMED: | 21488893 |
| PMCID: | PMC3727276 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: IMRED" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work