Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification Journal Article
| Authors: | Ou, S. H. I.; Kwak, E. L.; Siwak-Tapp, C.; Dy, J.; Bergethon, K.; Clark, J. W.; Camidge, D. R.; Solomon, B. J.; Maki, R. G.; Bang, Y. J.; Kim, D. W.; Christensen, J.; Tan, W.; Wilner, K. D.; Salgia, R.; Iafrate, A. J. |
| Article Title: | Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification |
| Abstract: | Crizotinib is a dual MET and ALK inhibitor. Currently, clinical development of crizotinib is focused primarily on ALK rearranged non-small cell lung cancer (NSCLC). Here we report an NSCLC patient with de novo MET amplification but no ALK rearrangement who achieved a rapid and durable response to crizotinib indicating is also a bona fide MET inhibitor. Copyright © 2011 by the International Association for the Study of Lung Cancer. |
| Keywords: | human tissue; treatment response; aged; fatigue; case report; bevacizumab; cancer combination chemotherapy; cancer growth; gemcitabine; cancer staging; follow up; lymph node metastasis; carboplatin; computer assisted tomography; multiple cycle treatment; gene amplification; lung non small cell cancer; tumor differentiation; smoking; coughing; lung adenocarcinoma; fluorescence in situ hybridization; gene rearrangement; cancer size; fluorodeoxyglucose f 18; computer assisted emission tomography; thorax radiography; gene dosage; lung biopsy; visual disorder; non-small cell lung cancer; lymphadenopathy; scatter factor receptor; sinus bradycardia; anaplastic lymphoma kinase; repeat procedure; visual acuity; 3 [1 (2,6 dichloro 3 fluorophenyl)ethoxy] 5 [1 (4 piperidinyl) 1h pyrazol 4 yl] 2 pyridinylamine; epithelial mesenchymal transition; slit lamp; 18f-fdg pet/ct; anaplastic lymphoma kinase (alk) re-arranged nsclc; crizotinib (pf02341066); de novo met amplification nsclc; met polysomy; chest tightness |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-05-01 |
| Start Page: | 942 |
| End Page: | 946 |
| Language: | English |
| DOI: | 10.1097/JTO.0b013e31821528d3 |
| PROVIDER: | scopus |
| PUBMED: | 21623265 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
