Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication Journal Article
| Authors: | Nakanishi, K.; Cavallo, F.; Perrouault, L.; Giovannangeli, C.; Moynahan, M. E.; Barchi, M.; Brunet, E.; Jasin, M. |
| Article Title: | Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication |
| Abstract: | Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand cross-links (ICLs) in mammalian cells. Cells from individuals with Fanconi anemia (FA) are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate. © 2011 Nature America, Inc. All rights reserved. |
| Keywords: | protein expression; gene mutation; nonhuman; flow cytometry; dna replication; ultraviolet radiation; mammalia; homologous recombination; cancer susceptibility; breast cancer; embryonic stem cell; green fluorescent protein; in vitro study; brca1 protein; brca2 protein; excision repair cross complementing protein 1; genetic transfection; binding protein; excision repair; protein deficiency; ku antigen; cell free system; oligonucleotide; epstein barr virus; dna cross linking; rad51 protein; fanconi anemia; xenopus laevis; epstein barr virus antigen 1; fanconi anemia group a protein |
| Journal Title: | Nature Structural and Molecular Biology |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 1545-9993 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-04-01 |
| Start Page: | 500 |
| End Page: | 503 |
| Language: | English |
| DOI: | 10.1038/nsmb.2029 |
| PROVIDER: | scopus |
| PMCID: | PMC3273992 |
| PUBMED: | 21423196 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: NSMBC" - "Source: Scopus" |
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