Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer Journal Article
| Authors: | Morris, L. G. T.; Sikora, A. G.; Hayes, R. B.; Patel, S. G.; Ganly, I. |
| Article Title: | Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer |
| Abstract: | Background: Patients with head and neck squamous cell carcinoma (HNSCC) are at significantly elevated risk of second primary malignancies (SPM), most commonly within the head and neck, lung, and esophagus (HNLE). Our objectives were to quantify the excess risk of SPM across all anatomic sites in which SPM risk is meaningfully elevated, including non-HNLE sites, in a large cohort of US patients. Methods: Population-based analysis of 75,087 patients with HNSCC in the SEER program, quantifying excess SPM risk by integrating relative (standardized incidence ratio; SIR) and absolute (excess absolute risk per 10,000 person-years at risk; EAR) statistics. Results: In HNSCC patients, the SIR of a second primary solid cancer was 2.2 (95% CI 2.1-2.2), corresponding to EAR of 167.7 additional cases per 10,000 person-years at risk. Over 1 year, 60 patients would need to be followed to observe one excess SPM. Lung cancer burden was most markedly elevated in absolute terms (EAR = 75.2), followed by HN (EAR = 59.8), esophageal (EAR = 14.2), and colorectal (EAR = 4.3) cancers. Lesser but significant excess risks were also observed for cancers of the bladder, liver, stomach, pancreas, kidney, salivary glands, nasopharynx, uterine cervix, and lymphoma. Conclusions: Data from a large population-based US cohort reveals that HNSCC patients experience markedly excess risk of SPM, predominantly in the HNLE sites. Furthermore, the risk of SPM is also meaningfully elevated, although to a lesser degree, in multiple other tobacco-associated sites. © 2011 Springer Science+Business Media B.V. |
| Keywords: | adult; controlled study; major clinical study; squamous cell carcinoma; cancer risk; united states; pancreas cancer; colorectal cancer; cohort analysis; lung cancer; bladder cancer; risk assessment; population research; uterine cervix cancer; lymphoma; lung; cancer registry; stomach cancer; liver cancer; malignancy; high risk population; salivary gland cancer; second cancer; kidney cancer; esophagus cancer; nasopharynx cancer; head and neck; colon; esophagus; head and neck carcinoma; second primary; standardized incidence ratio |
| Journal Title: | Cancer Causes & Control |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 0957-5243 |
| Publisher: | Springer |
| Date Published: | 2011-05-01 |
| Start Page: | 671 |
| End Page: | 679 |
| Language: | English |
| DOI: | 10.1007/s10552-011-9739-2 |
| PROVIDER: | scopus |
| PMCID: | PMC3085084 |
| PUBMED: | 21327458 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: CCCNE" - "Source: Scopus" |
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