Addition of pamidronate to chemotherapy for the treatment of osteosarcoma Journal Article
| Authors: | Meyers, P. A.; Healey, J. H.; Chou, A. J.; Wexler, L. H.; Merola, P. R.; Morris, C. D.; LaQuaglia, M. P.; Kellick, M. G.; Abramson, S. J.; Gorlick, R. |
| Article Title: | Addition of pamidronate to chemotherapy for the treatment of osteosarcoma |
| Abstract: | Background: This study evaluated the safety and feasibility of the addition of pamidronate to chemotherapy for treatment of osteosarcoma. Methods: The authors treated 40 patients with osteosarcoma with cisplatin, doxorubicin, and methotrexate with the addition of pamidronate 2 mg/kg/dose (max dose 90 mg) monthly for 12 doses. Survival, event-free survival (EFS), and durability of orthopedic reconstruction were evaluated. Results: For patients with localized disease, event-free survival (EFS) at 5 years was 72% and overall survival 93%. For patients with metastatic disease, EFS at 5 years was 45% and overall survival 64%. Toxicity was similar to patients treated with chemotherapy alone. Thirteen of 14 uncemented implants demonstrated successful osteointegration. Among allograft reconstructions, there were 2 graft failures, 4 delayed unions, and 6 successful grafts. Overall, 5 of 33 reconstructions failed. There were no stress fractures or growth disturbances. Conclusions: Pamidronate can be safely incorporated with chemotherapy for the treatment of osteosarcoma. It does not impair the efficacy of chemotherapy. Pamidronate may improve the durability of limb reconstruction. © 2010 American Cancer Society. |
| Keywords: | osteosarcoma; adolescent; adult; child; clinical article; event free survival; school child; fracture; survival rate; overall survival; paresthesia; cisplatin; doxorubicin; drug safety; chemotherapy; methotrexate; drug megadose; multiple cycle treatment; nephrotoxicity; bisphosphonates; survival time; graft failure; drug response; hypocalcemia; ototoxicity; bone allograft; fracture nonunion; pamidronic acid; oral paresthesia; jaw osteonecrosis; endoprosthetic reconstruction; limb-sparing surgery; pamidronate |
| Journal Title: | Cancer |
| Volume: | 117 |
| Issue: | 8 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2011-04-15 |
| Start Page: | 1736 |
| End Page: | 1744 |
| Language: | English |
| DOI: | 10.1002/cncr.25744 |
| PROVIDER: | scopus |
| PMCID: | PMC3059356 |
| PUBMED: | 21472721 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: CANCA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work