Autoantibodies against cancer antigens Journal Article
| Authors: | Gnjatic, S.; Old, L. J.; Chen, Y. T. |
| Article Title: | Autoantibodies against cancer antigens |
| Abstract: | With the identification of tumor antigens, the host immune response to various types of cancers can now be studied with a high degree of specificity in large cohorts of patients, in the hope of correlating immunity with clinical events and defining immunotherapeutic strategies. Several antigens, such as NY-ESO-1, p53, or SOX2, have attracted attention because of their frequent spontaneous immunogenicity in cancer patients, notably in their ability to induce humoral responses. We describe in this chapter a simple implementation of a serological monitoring platform for autoantibody measurement in cancer patients, from production of recombinant antigens to ELISA testing and interpretation. |
| Keywords: | methodology; tumor antigen; enzyme linked immunosorbent assay; immunology; antigens, neoplasm; blood sampling; enzyme-linked immunosorbent assay; molecular biology; autoantibody; autoantibodies; blood specimen collection |
| Journal Title: | Methods in Molecular Biology |
| Volume: | 520 |
| ISSN: | 1064-3745 |
| Publisher: | Humana Press Inc |
| Date Published: | 2009-01-01 |
| Start Page: | 11 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1007/978-1-60327-811-9_2 |
| PUBMED: | 19381944 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 2 in "Tumor Biomarker Discovery: Methods and Protocols" (ISBN: 978-1-60327-810-2)--- Cited By (since 1996): 6 - Export Date: 30 November 2010 - Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work