A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus Journal Article


Authors: Ilson, D. H.; Kelsen, D.; Shah, M.; Schwartz, G.; Levine, D. A.; Boyd, J.; Capanu, M.; Miron, B.; Klimstra, D.
Article Title: A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus
Abstract: BACKGROUND: Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) have activity in solid tumors. The authors evaluated an oral EGFR TKI, erlotinib, in patients with previously treated esophageal cancer. METHODS: Thirty patients with measurable, metastatic cancer of the esophageal and gastroesophageal junction received 150 mg erlotinib daily. EGFR-negative tumors (6 patients; 20%) and EGFR-over expressing tumors (24 patients; 80%) were treated. Most patients were men (70%) with adenocarcinoma (57%) and had received previous chemotherapy (97%). RESULTS: Two partial responses were observe d in the EGFR-positive cohort (2 of 24 patients; 8%), and no responses were observed in the EGFR-negative cohort (0 of 6 patients). Reponses were limited to patients who had squamous cell carcinoma (2 of 13 patients; 15%; response duration, 5.5-7 months). The time to tumor progression was longer in patients who had squamous cell carcinoma (3.3 months; range, 1-24 months) compared with patients who had adenocarcinoma (1.6 months; range, 1-6 months; P =.026). Therapy was tolerable with the expected toxicity of skin rash (grade 1-2, 67%; grade 3, 10%). CONCLUSIONS: Erlotinib had limited activity in patients with esophageal cancer, and responses and some protracted stable disease were observed in those with squamous cell carcinoma. Efficacy according to EGFR status could not be assessed given the rarity of EGFR-negative tumors. The current results indicated that further evaluation of this agent in squamous cell carcinoma is warranted. Cancer 2011. © 2010 American Cancer Society.
Keywords: clinical article; treatment outcome; aged; middle aged; unclassified drug; overall survival; mutation; drug tolerability; squamous cell carcinoma; carcinoma, squamous cell; erlotinib; diarrhea; drug dose reduction; drug efficacy; antineoplastic agents; adenocarcinoma; gene overexpression; progression free survival; phase 2 clinical trial; epidermal growth factor receptor; receptor, epidermal growth factor; rash; metastasis potential; tumor growth; quinazolines; esophageal adenocarcinoma; retreatment; esophageal neoplasms; esophageal cancer; squamous cancer; response evaluation; nsc 71871
Journal Title: Cancer
Volume: 117
Issue: 7
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2011-04-01
Start Page: 1409
End Page: 1414
Language: English
DOI: 10.1002/cncr.25602
PUBMED: 21425140
PROVIDER: scopus
PMCID: PMC3116987
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "CODEN: CANCA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Gary Schwartz
    364 Schwartz
  2. Douglas A Levine
    356 Levine
  3. Marinela Capanu
    211 Capanu
  4. David S Klimstra
    852 Klimstra
  5. Manish Shah
    175 Shah
  6. David H Ilson
    275 Ilson
  7. David P Kelsen
    341 Kelsen
  8. Benjamin Miron
    4 Miron