Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: A report from the Childhood Cancer Survivor Study Journal Article
| Authors: | Green, D. M.; Nolan, V. G.; Kawashima, T.; Stovall, M.; Donaldson, S. S.; Srivastava, D.; Leisenring, W.; Robison, L. L.; Sklar, C. A. |
| Article Title: | Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: A report from the Childhood Cancer Survivor Study |
| Abstract: | Objective: To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy. Design: Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers. Setting: Self-administered questionnaire. Patient(s): A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (≤0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants. Intervention(s): None. Main Outcome Measure(s): Self-reported pregnancy events. Result(s): As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97-1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses ≥22 Gy compared with those CCS receiving no HPT RT. Conclusion(s): These results support the hypothesis that exposures of 22-27 Gy HPT RT may be a contributing factor to infertility among female CCS. © 2011 by American Society for Reproductive Medicine. |
| Keywords: | major clinical study; cancer radiotherapy; radiation dose; alkylating agent; childhood cancer; cancer survivor; risk assessment; questionnaire; pregnancy; female fertility; childhood cancer survivor; hypothalamic irradiation; pituitary irradiation; hypothalamic pituitary radiation |
| Journal Title: | Fertility and Sterility |
| Volume: | 95 |
| Issue: | 6 |
| ISSN: | 0015-0282 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-05-01 |
| Start Page: | 1922 |
| End Page: | 1927.e1 |
| Language: | English |
| DOI: | 10.1016/j.fertnstert.2011.02.002 |
| PROVIDER: | scopus |
| PMCID: | PMC3080448 |
| PUBMED: | 21376314 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: FESTA" - "Source: Scopus" |
