Endometrial undifferentiated carcinomas Journal Article
| Authors: | Garg, K.; Soslow, R. A. |
| Article Title: | Endometrial undifferentiated carcinomas |
| Abstract: | Undifferentiated carcinomas of the endometrium are uncommon neoplasms that are likely underdiagnosed. They are important to recognize because they are clinically aggressive tumors that can occur in very young patients. They have a broad histologic differential diagnosis but demonstrate specific histologic features that should enable accurate diagnosis. They typically consist of sheets of dyshesive, monotonous, ovoid cells, although occasional cases can display focal nuclear pleomorphism. Many of these tumors show foci of rhabdoid cells in a background of myxoid stroma. They may be accompanied by a component of well-differentiated to moderately differentiated endometrioid adenocarcinoma. These tumors are frequently misdiagnosed, most often as FIGO grade 3 endometrioid carcinoma, carcinosarcoma, high-grade sarcoma, and neuroendocrine carcinoma. By immunohistochemistry, they usually show only focal keratin and/or epithelial membrane antigen staining.Undifferentiated carcinomas can occur in young women; they typically present at high stages and may pursue a fulminant clinical course. A proportion are associated with defects in the DNA mismatch repair system, including Lynch syndrome. Copyright © 2011 by Lippincott Williams & Wilkins. |
| Keywords: | immunohistochemistry; adult; human tissue; unclassified drug; gene mutation; gene deletion; histopathology; review; case report; endometrioid carcinoma; endometrium carcinoma; undifferentiated carcinoma; cancer grading; diagnostic accuracy; differential diagnosis; genetic association; cell differentiation; cancer invasion; diagnostic error; mismatch repair protein; protein msh2; protein msh6; mismatch repair protein pms2; genetic counseling; endometrium; endometrium biopsy; hereditary nonpolyposis colorectal cancer; epithelial membrane antigen; carcinosarcoma; vagina bleeding; mismatch repair protein mlh1; endometrial undifferentiated carcinoma; endometrioid adenocarcinoma |
| Journal Title: | Pathology Case Reviews |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 1082-9784 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2011-05-01 |
| Start Page: | 115 |
| End Page: | 118 |
| Language: | English |
| DOI: | 10.1097/PCR.0b013e318217342d |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
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