Complications after craniofacial resection for malignant tumors: Are complication trends changing? Journal Article
| Authors: | Gil, Z.; Patel, S. G.; Bilsky, M.; Shah, J. P.; Kraus, D. H. |
| Article Title: | Complications after craniofacial resection for malignant tumors: Are complication trends changing? |
| Abstract: | Objective: To determine the rate and type of complications after craniofacial resection (CFR) during the most recent 10-year period in comparison to a historic control. Methods: Patients underwent CFR in 1973-1995 ("earlier" period; n = 114) and in 1996-2005 ("later" period; n = 120) before and after a broad-spectrum antibiotic regime was used. Results: In the later period patients had higher rates of comorbidity, dural invasion, high-grade malignancy, and wide resections (P < 0.02). Complications were identified in 52 percent of the early and 33 percent of the later groups (P = 0.002). There was 20 percent decrease in wound complications in the later period (P < 0.0001), but not in other complications. In the earlier period, complications were evenly distributed between patients younger and older than 50 years. However, in the later period, most complications occurred among elderly patients. Multivariate analysis revealed that a broad-spectrum antibiotic regime was associated with a lower complication rate (P = 0.02). Conclusions: Complication rates decreased during the last 10 years due to a decline in wound infections. Broad-spectrum antibiotic coverage probably contributed to this change. © 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. |
| Keywords: | adult; controlled study; aged; middle aged; antibiotic agent; surgical technique; retrospective studies; major clinical study; fistula; cohort studies; facial neoplasms; incidence; risk factors; graft necrosis; postoperative complication; postoperative complications; statistical significance; heart infarction; urinary tract infection; comorbidity; malignant neoplastic disease; multivariate analysis; skull base neoplasms; heart arrhythmia; encephalitis; lung infection; diplopia; wound infection; antibiotic prophylaxis; wound dehiscence; blindness; brain hematoma; craniofacial surgery; liquorrhea; meningitis; orbit cellulitis; pneumocephalus; skull base tumor; wound complication; cranial fossa, anterior |
| Journal Title: | Otolaryngology - Head and Neck Surgery |
| Volume: | 140 |
| Issue: | 2 |
| ISSN: | 0194-5998 |
| Publisher: | Sage Publications |
| Date Published: | 2009-02-01 |
| Start Page: | 218 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.1016/j.otohns.2008.10.042 |
| PUBMED: | 19201292 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: OTOLD" - "Source: Scopus" |
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