Survival in epithelial ovarian cancer: A multivariate analysis incorporating BRCA mutation status and platinum sensitivity Journal Article
| Authors: | Gallagher, D. J.; Konner, J. A.; Bell-Mcguinn, K. M.; Bhatia, J.; Sabbatini, P.; Aghajanian, C. A.; Offit, K.; Barakat, R. R.; Spriggs, D. R.; Kauff, N. D. |
| Article Title: | Survival in epithelial ovarian cancer: A multivariate analysis incorporating BRCA mutation status and platinum sensitivity |
| Abstract: | Background: Patients with BRCA-associated ovarian cancer (OC) have a survival advantage over those with sporadic OC. To further explore this, we examined the impact of prognostic factors on disease-free survival (DFS) and overall survival (OS) in patients with known BRCA mutation status. Patients and methods: We reviewed stage III-IV OC patients treated at our institution between 1 December 1996 and 30 September 2006 and also tested on protocol for BRCA mutations. Impact on DFS and OS was determined by Kaplan-Meier analysis and a Cox proportional hazards model. Results: Of the 110 patients, 36 had deleterious BRCA mutations [BRCA (+)] and 74 were BRCA wild type [BRCA(2)]. Thirty-one of 36 (86%) BRCA (+) and 60 of 74 (81%) BRCA (2) patients were platinum sensitive (P = 0.60). Median OS was longer for BRCA (+) patients (not reached versus 67.8 months; P = 0.02), but DFS was similar (26.9 versus 24.0, P = 0.3). On multivariate analysis, OS correlated with primary platinum sensitivity [HR = 0.15; 95% CI (confidence interval) 0.06-0.34] and BRCA (+) mutation status (HR = 0.33; 95% CI 0.12-0.86). Conclusions: BRCA mutation status predicted OS independent of primary platinum sensitivity, suggesting that underlying tumor biology contributes to disease outcome and may be worthy of consideration in future clinical trial design. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | survival; adult; controlled study; aged; gene mutation; major clinical study; overall survival; gene deletion; disease free survival; cancer staging; ovarian cancer; ovary cancer; wild type; oncogene; correlation analysis; platinum complex; brca; platinum sensitivity |
| Journal Title: | Annals of Oncology |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2011-05-01 |
| Start Page: | 1127 |
| End Page: | 1132 |
| Language: | English |
| DOI: | 10.1093/annonc/mdq577 |
| PROVIDER: | scopus |
| PUBMED: | 21084428 |
| PMCID: | PMC6267858 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: ANONE" - "Source: Scopus" |
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MSK Authors
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788Offit -
629Barakat -
128Kauff -
155Konner -
262Sabbatini -
43Gallagher -
607Aghajanian -
60Bell-McGuinn -
325Spriggs -
12
Bhatia
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