Current recommendations for systemic therapy of recurrent and/or metastatic head and neck squamous cell cancer Journal Article
| Authors: | Fury, M. G.; Pfister, D. G. |
| Article Title: | Current recommendations for systemic therapy of recurrent and/or metastatic head and neck squamous cell cancer |
| Abstract: | For palliation of patients with recurrent and/or metastatic head and neck squamous cell cancer (R/M HNSCC), the major classes of commonly used cytotoxic chemotherapeutic agents are platinum agents (cisplatin, carboplatin), taxanes (paclitaxel, docetaxel), and antimetabolic agents (methotrexate, 5-fluorouracil). Cetuximab, a monoclonal antibody directed against the extracellular domain of the epidermal growth factor receptor, also shows modest activity against R/M HNSCC. Because the overall management of patients with R/M HNSCC often involves multidisciplinary input, this review focuses on data that help guide decision-making in scenarios in which palliative chemotherapy is planned. Avenues for ongoing research are also presented. © JNCCN-Journal of the National Comprehensive Cancer Network. |
| Keywords: | cisplatin; paclitaxel; cetuximab; head and neck; metastatic; squamous cancer |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 9 |
| Issue: | 6 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2011-06-01 |
| Start Page: | 681 |
| End Page: | 690 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 21636539 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
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