Variable MR imaging appearances of focal nodular hyperplasia in pediatric cancer patients Journal Article


Authors: Do, R. K. G.; Shaylor, S. D.; Shia, J.; Wang, A.; Kramer, K.; Abramson, S. J.; Price, A. P.; Schwartz, L. H.
Article Title: Variable MR imaging appearances of focal nodular hyperplasia in pediatric cancer patients
Abstract: Background: Focal nodular hyperplasia (FNH) is rare in the general pediatric population but is increasingly found in treated pediatric cancer patients. FNH can be incidentally found on CT and MRI and can be misdiagnosed as liver metastasis in patients with an oncological history. Objective: To describe the MR imaging findings of FNH in pediatric cancer patients. Materials and methods: Ten children who had been treated for a primary malignancy and who were diagnosed with FNH from 2003 to 2010 were identified from a search for FNH in our pathology and radiology databases. Patients were included if they were treated for a primary malignancy and had undergone MR imaging of the liver including T1-weighted, T2-weighted and dynamic contrast-enhanced T1-weighted sequences. Results: FNH from all patients (n=10) demonstrated typical homogeneous arterial enhancement on MRI. The FNH was often multiple and small (7/10 patients), lacking a central scar, with variable imaging characteristics including signal hyperintensity on both T1- and T2-weighted images (4/10 patients), especially in the setting of hepatic hemosiderosis. Conclusion: FNH has a variable MR appearance in pediatric cancer patients and should be considered in the differential diagnosis of hypervascular liver lesions. © 2011 Springer-Verlag.
Keywords: adolescent; cancer chemotherapy; child; clinical article; preschool child; school child; primary tumor; clinical feature; histopathology; cancer patient; cancer radiotherapy; nuclear magnetic resonance imaging; positron emission tomography; follow up; image analysis; differential diagnosis; stem cell transplantation; hematopoietic stem cell transplantation; data base; medical record review; retrospective study; childhood cancer; hodgkin disease; disease severity; nonhodgkin lymphoma; neuroblastoma; contrast enhancement; rhabdomyosarcoma; gadolinium pentetate; children; liver parenchyma; liver biopsy; mri; desmoid tumor; desmoplastic small round cell tumor; focal nodular hyperplasia; hemosiderosis; liver focal nodular hyperplasia; liver hemosiderosis
Journal Title: Pediatric Radiology
Volume: 41
Issue: 3
ISSN: 0301-0449
Publisher: Springer  
Date Published: 2011-03-01
Start Page: 335
End Page: 340
Language: English
DOI: 10.1007/s00247-010-1956-4
PROVIDER: scopus
PUBMED: 21170523
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "CODEN: PDRYA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Anita P Price
    34 Price
  2. Kim Kramer
    168 Kramer
  3. Jinru Shia
    450 Shia
  4. Kinh Gian Do
    112 Do