MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome Journal Article
| Authors: | Cámara, Y.; Asin-Cayuela, J.; Park, C. B.; Metodiev, M. D.; Shi, Y.; Ruzzenente, B.; Kukat, C.; Habermann, B.; Wibom, R.; Hultenby, K.; Franz, T.; Erdjument-Bromage, H.; Tempst, P.; Hallberg, B. M.; Gustafsson, C. M.; Larsson, N. G. |
| Article Title: | MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome |
| Abstract: | Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria. © 2011 Elsevier Inc. |
| Keywords: | controlled study; unclassified drug; nonhuman; mouse; embryo; protein targeting; animal experiment; animal model; embryo development; methyltransferase; mammal; mitochondrial protein; mitochondrion; cardiomyopathy; ribosome; translation regulation; mitochondrial transcription termination factor 4; nsun4 methyltransferase |
| Journal Title: | Cell Metabolism |
| Volume: | 13 |
| Issue: | 5 |
| ISSN: | 1550-4131 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-05-04 |
| Start Page: | 527 |
| End Page: | 539 |
| Language: | English |
| DOI: | 10.1016/j.cmet.2011.04.002 |
| PROVIDER: | scopus |
| PUBMED: | 21531335 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
