Opiate pharmacology and relief of pain Journal Article
| Author: | Pasternak, G. W. |
| Article Title: | Opiate pharmacology and relief of pain |
| Abstract: | Opioids remain the mainstay of severe pain management in patients with cancer. The hallmark of pain management is individualization of therapy. Although almost all clinically used drugs act through mu opioid receptors, they display subtle but important differences pharmacologically. Furthermore, not all patients respond equally well to all drugs. Evidence suggests that these variable responses among patients have a biologic basis and are likely to involve both biased agonism and the many mu opioid receptor subtypes that have been cloned. (C) 2014 by American Society of Clinical Oncology |
| Keywords: | mice; splice variants; tolerance; heroin; mechanisms; rat-brain; cloning; morphine analgesia; mu-opioid receptor; 7-transmembrane receptors |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 32 |
| Issue: | 16 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2014-06-01 |
| Start Page: | 1655 |
| End Page: | 1661 |
| Language: | English |
| ACCESSION: | WOS:000337156700004 |
| DOI: | 10.1200/jco.2013.53.1079 |
| PROVIDER: | wos |
| PMCID: | PMC4031189 |
| PUBMED: | 24799496 |
| Notes: | Review -- Source: Wos |
