Phase 2 study of weekly bortezomib in mantle cell and follicular lymphoma Journal Article

   


Authors: Gerecitano, J.; Portlock, C.; Moskowitz, C.; Hamlin, P.; Straus, D.; Zelenetz, A. D.; Zhang, Z.; Dumitrescu, O.; Sarasohn, D.; Lin, D.; Pappanicholaou, J.; Cortelli, B. M.; Neylon, E.; Hamelers, R.; Wright, J.; O'Connor, O. A.
Article Title: Phase 2 study of weekly bortezomib in mantle cell and follicular lymphoma
Abstract: Twice-weekly bortezomib has proven activity in mantle cell (MCL) and indolent lymphomas. This study explored a weekly schedule of bortezomib in follicular lymphoma (FL) and MCL. Although weekly bortezomib was better tolerated, the overall response rate (ORR) was inferior (18% vs. 50%, P = 0.02) with no complete remissions (CR) (compared with 18% CR for the twice-weekly schedule). Progression-free survival (PFS) was not different. The weekly schedule of bortezomib was less toxic, but yielded fewer and lower quality responses than twice-weekly bortezomib. Given the similar PFS, the weekly schedule may still be appropriate for some patients.
Keywords: aged; aged, 80 and over; disease-free survival; middle aged; clinical trial; antineoplastic agents; disease free survival; antineoplastic agent; bortezomib; phase 2 clinical trial; boronic acids; protease inhibitors; pyrazines; follicular lymphoma; boronic acid derivative; proteinase inhibitor; pyrazine derivative; lymphoma, follicular
Journal Title: British Journal of Haematology
Volume: 146
Issue: 6
ISSN: 0007-1048
Publisher: John Wiley & Sons  
Date Published: 2009-09-01
Start Page: 652
End Page: 655
Language: English
PUBMED: 19624539
PROVIDER: scopus
PMCID: PMC4035037
DOI: 10.1111/j.1365-2141.2009.07775.x
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-68949093334&partnerID=40&md5=2611a86c3a9e6ea210a593d5caf99d8b
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "Source: Scopus"
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MSK Authors
  1. Zhigang Zhang
    428 Zhang
  2. Carol Portlock
    204 Portlock
  3. Craig Moskowitz
    407 Moskowitz
  4. Debra Marion Sarasohn
    48 Sarasohn
  5. John Frank Gerecitano
    153 Gerecitano
  6. Otilia-Liana Dumitrescu
    14 Dumitrescu
  7. Andrew D Zelenetz
    767 Zelenetz
  8. Paul Hamlin
    277 Hamlin
  9. David J Straus
    356 Straus
  10. Jennifer Pappanicholaou
    5 Pappanicholaou
  11. Dorothy S Lin
    4 Lin
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