Chemotherapy-associated hepatotoxicity and hepatic resection for metastatic colorectal cancer Journal Article
| Authors: | Wang, S. C.; D'Angelica, M. I. |
| Article Title: | Chemotherapy-associated hepatotoxicity and hepatic resection for metastatic colorectal cancer |
| Abstract: | Approximately 50 % of patients with colorectal cancer will develop liver metastases. Complete resection is associated with 50 % five-year overall survival and 20 % long-term cure. Use of preoperative chemotherapy for patients with resectable colorectal metastasis to the liver is controversial. Among the arguments against use of preoperative chemotherapy is the resulting hepatotoxicity, which may increase the risk of hepatectomy. In this review, we assess the liver-specific toxicity profiles of the most commonly used chemotherapy agents and how this toxicity affects perioperative outcomes. We also comment on the use of neoadjuvant chemotherapy for patients with resectable colorectal metastasis. © 2014 Springer Science+Business Media New York. |
| Keywords: | cancer chemotherapy; treatment outcome; cancer surgery; overall survival; postoperative period; bevacizumab; fluorouracil; preoperative care; neoadjuvant therapy; follow up; antineoplastic agent; liver toxicity; morbidity; cetuximab; cancer mortality; irinotecan; postoperative complication; liver failure; length of stay; adjuvant chemotherapy; long term care; liver resection; liver cell; oxaliplatin; liver parenchyma; 5-fluorouracil; portal vein; steatosis; recurrence free survival; metastatic colorectal cancer; liver venoocclusive disease; nonalcoholic fatty liver; sinusoidal obstruction syndrome; 5-fu; first pass effect; steatohepatitis; haip; colorectal liver metastasis; human; article; chemotherapy-associated hepatotoxicity; chemotherapy-associated steatohepatitis; hepatic artery infusion pump; nodular regenerative hyperplasia; liver hyperplasia |
| Journal Title: | Current Colorectal Cancer Reports |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 1556-3790 |
| Publisher: | Springer |
| Date Published: | 2014-06-01 |
| Start Page: | 195 |
| End Page: | 203 |
| Language: | English |
| DOI: | 10.1007/s11888-014-0218-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- Source: Scopus |
