Diagnosis of pernicious anemia and the risk of pancreatic cancer Journal Article


Authors: Shah, P.; Rhim, A. D.; Haynes, K.; Hwang, W. T.; Yang, Y. X.
Article Title: Diagnosis of pernicious anemia and the risk of pancreatic cancer
Abstract: OBJECTIVES: A number of studies have demonstrated a trophic effect of gastrin on pancreatic cancer cells in vitro. Pernicious anemia (PA) is a clinical condition characterized by chronic hypergastrinemia. The aim of this study was to determine if PA is a risk factor for pancreatic cancer. METHODS: This study is a retrospective cohort study using The Health Improvement Network database, which contains comprehensive health information on 7.5 million patients in the United Kingdom from 1993 to 2009. All patients with PA in the study cohort were identified and composed of the exposed group. Each exposed patient was matched on practice site, sex, and age with up to 4 unexposed patients without PA. The outcome was incident pancreatic cancer. The hazard ratio and 95% confidence intervals were estimated using multivariable Cox regression analysis. RESULTS: We identified 15,324 patients with PA and 55,094 unexposed patients. Mean follow-up time was similar between groups (exposed 4.31 [SD, 3.38] years, unexposed 4.63 [SD, 3.44] years). The multivariable adjusted hazard ratio for pancreatic cancer associated with PA was 1.16 (95% confidence interval, 0.77-1.76; P = 0.47). CONCLUSIONS: There is no significant association between PA and the risk of pancreatic cancer. © 2014 by Lippincott Williams & Wilkins.
Keywords: aged; major clinical study; cancer risk; pancreas cancer; follow up; disease association; cohort analysis; risk factor; proton pump inhibitor; pancreatic cancer; united kingdom; hypergastrinemia; gastrin; pernicious anemia; human; male; female; priority journal; article; stomach acid
Journal Title: Pancreas
Volume: 43
Issue: 3
ISSN: 0885-3177
Publisher: Lippincott Williams & Wilkins  
Date Published: 2014-04-01
Start Page: 422
End Page: 426
Language: English
DOI: 10.1097/mpa.0000000000000054
PROVIDER: scopus
PMCID: PMC4015141
PUBMED: 24622073
DOI/URL:
Notes: Export Date: 1 August 2014 -- CODEN: PANCE -- Source: Scopus
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  1. Pari Mayank Shah
    47 Shah