Laser interstitial thermal therapy for treatment of post-radiosurgery tumor recurrence and radiation necrosis Journal Article
| Authors: | Patel, T. R.; Chiang, V. L. S. |
| Article Title: | Laser interstitial thermal therapy for treatment of post-radiosurgery tumor recurrence and radiation necrosis |
| Abstract: | Background and objective: Approximately one-third of all intracranial metastatic lesions treated with stereotactic radiosurgery (SRS) will regrow at some point during follow-up. A fraction of these lesions will require further therapy. Traditional approaches will work in a majority of, but not all, cases. Laser interstitial thermal therapy (LITT) represents a promising strategy for treatment of regrowing lesions post-SRS that are refractory to standard therapies. Materials and methods: Published literature to evaluate the role of LITT for treatment of regrowing metastatic lesions post-SRS is reviewed; own single institution experience treating these pathologies with two different commercially available LITT systems is included. Results: Early clinical studies have established that LITT can be used to successfully treat post-SRS regrowing lesions. Patients treated with LITT demonstrate both clinical and radiographic improvements following treatment, with minimal side effects. Conclusions: LITT is a promising new therapy for the management of post-SRS regrowing intracranial metastases. Large-scale clinical trials demonstrating therapeutic efficacy must be completed prior to widespread adoption of this technique. |
| Keywords: | adult; aged; middle aged; review; case report; treatment planning; nuclear magnetic resonance imaging; brain tumor; follow up; enzyme inhibition; breast cancer; lung non small cell cancer; radiotherapy; patient monitoring; pathology; tumors; tumor recurrence; brain metastasis; medline; robotics; stereotactic radiosurgery; stereotactic procedure; stereotactic biopsy; radiation necrosis; therapeutic efficacy; cooling; brain metastases; central nervous system disease; metastatic melanoma; laser interstitial thermal therapy; laser thermotherapy; thermometry; vemurafenib; metastatic lesions; susceptibility weighted imaging; human; male; female; tumor regrowth; laser interstitial thermal therapies; traditional approaches; tumor recurrences |
| Journal Title: | Photonics and Lasers in Medicine |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 2193-0643 |
| Publisher: | Walter de Gruyter GmbH |
| Date Published: | 2014-02-01 |
| Start Page: | 95 |
| End Page: | 105 |
| Language: | English |
| DOI: | 10.1515/plm-2013-0057 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):1 -- Export Date: 1 August 2014 -- Source: Scopus |
