Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T cell-depleted peripheral blood and cord blood stem cell transplantations Journal Article


Authors: Lee, Y. J.; Zheng, J.; Kolitsopoulos, Y.; Chung, D.; Amigues, I.; Son, T.; Choo, K.; Hester, J.; Giralt, S. A.; Glezerman, I. G.; Jakubowski, A. A.; Papanicolaou, G. A.
Article Title: Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T cell-depleted peripheral blood and cord blood stem cell transplantations
Abstract: Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. We prospectively monitored 98 patients who had received HSCT by serial BKV PCR in the urine through day (D) +100 to analyze the relationship between BK viruria and HC, serum creatinine (Cr), and creatinine clearance (CrCl) through D +180 or death. Patients, median age 52 years (range, 20 to 73), received T cell-depleted (50%) or cord blood allografts (21%). Median pre-HSCT BKV IgG titers were 1:10,240. Incremental increase in BKV IgG titers correlated with developing BK viruria ≥ 107 copies/mL. By D +100, 53 (54%) patients had BK viruria. BKV load in the urine increased at engraftment and persisted throughout D +100. HC developed in 10 patients (10%); 7 of 10 with BK viruria. In competing risk analyses, BK viruria ≥ 107 copies/mL, older age, cytomegalovirus reactivation, and foscarnet use were risk factors for HC. Cr and CrCl at 2, 3, and 6 months after HSCT were similar between patients with and without BK viruria. © 2014 American Society for Blood and Marrow Transplantation.
Keywords: hematopoietic stem cell transplantation; hemorrhagic cystitis; renal function; bk virus
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 20
Issue: 8
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2014-08-01
Start Page: 1204
End Page: 1210
Language: English
DOI: 10.1016/j.bbmt.2014.04.017
PROVIDER: scopus
PMCID: PMC4099262
PUBMED: 24769326
DOI/URL:
Notes: Export Date: 1 August 2014 -- CODEN: BBMTF -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    152 Zheng
  2. Yeon Joo Lee
    31 Lee
  3. Sergio Andres Giralt
    617 Giralt
  4. Tammy Son
    14 Son
  5. Dick Chung
    13 Chung
  6. Kathleen M Choo
    12 Choo