STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics Journal Article
| Authors: | Kerns, S. L.; Ruysscher, D. D.; Andreassen, C. N.; Azria, D.; Barnett, G. C.; Chang-Claude, J.; Davidson, S.; Deasy, J. O.; Dunning, A. M.; Ostrer, H.; Rosenstein, B. S.; West, C. M. L.; Bentzen, S. M. |
| Article Title: | STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics |
| Abstract: | Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced in independent validation studies. A major reason for these inconsistencies is a high number of false positive findings because no adjustments were made for multiple comparisons. It is also possible that some validation studies were false negatives due to methodological shortcomings or a failure to reproduce relevant details of the original study. Transparent reporting is needed to ensure these flaws do not hamper progress in radiogenomics. In response to the need for improving the quality of research in the area, the Radiogenomics Consortium produced an 18-item checklist for reporting radiogenomics studies. It is recognised that not all studies will have recorded all of the information included in the checklist. However, authors should report on all checklist items and acknowledge any missing information. Use of STROGAR guidelines will advance the field of radiogenomics by increasing the transparency and completeness of reporting. © 2013 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | single nucleotide polymorphism; genetics; review; intensity modulated radiation therapy; cancer radiotherapy; follow up; quality control; genetic association; genetic variability; genotype; gene frequency; practice guideline; radiation injury; radiation exposure; radiation response; prostate cancer; medical information; head and neck cancer; radiation dose fractionation; brachytherapy; genomics; telangiectasia; erectile dysfunction; radiation dose distribution; radiation pneumonia; reporting guidelines; secondary analysis; randomized controlled trial (topic); genotype phenotype correlation; normal tissue toxicity; checklist; gene linkage disequilibrium; confounding variable; human; priority journal; radiogenomics |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 110 |
| Issue: | 1 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-01-01 |
| Start Page: | 182 |
| End Page: | 188 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2013.07.011 |
| PROVIDER: | scopus |
| PUBMED: | 23993398 |
| PMCID: | PMC4786020 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):3 -- Export Date: 1 August 2014 -- CODEN: RAOND -- Source: Scopus |
