Repair of strand breaks by homologous recombination Journal Article
| Authors: | Jasin, M.; Rothstein, R. |
| Article Title: | Repair of strand breaks by homologous recombination |
| Abstract: | In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies. |
| Keywords: | dna binding protein; genetics; dna-binding proteins; review; methodology; animal; meiosis; metabolism; animals; homologous recombination; dna repair; genetic recombination; genetic engineering; saccharomyces cerevisiae; recombination, genetic; plasmid; dna breaks, double-stranded; double stranded dna break; plasmids; rad51 protein; rad51 recombinase; humans; human |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 5 |
| Issue: | 11 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2013-11-01 |
| Start Page: | a012740 |
| Language: | English |
| PUBMED: | 24097900 |
| PROVIDER: | scopus |
| DOI: | 10.1101/cshperspect.a012740 |
| PMCID: | PMC3809576 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):1 -- Export Date: 1 August 2014 -- Source: Scopus |
