Mitochondrial protein quality control during biogenesis and aging Journal Article
| Authors: | Baker, B. M.; Haynes, C. M. |
| Article Title: | Mitochondrial protein quality control during biogenesis and aging |
| Abstract: | Mitochondrial dysfunction has long been associated with the aging process and the onset of numerous diseases. Regulation of the complex protein-folding environment within the organelle is essential for maintaining efficient metabolic output. Over time, dysregulation of protein homeostasis arises through stress induced by the accumulation of reactive oxygen species and mutations in the mitochondrial genome introduced during replication. To preserve organelle function during biogenesis, remodeling and stress, quality control of mitochondrial proteins must be monitored by molecular chaperones and proteases stationed in the four compartments of the organelle. Here, we review mitochondrial protein quality control with a focus on organelle biogenesis and aging. © 2011 Elsevier Ltd. |
| Keywords: | review; nonhuman; dna replication; protein domain; neoplasm; quality control; proteasome; protein assembly; protein degradation; extracellular matrix; endoplasmic reticulum; protein processing; transcription regulation; ubiquitination; cell damage; protein transport; reactive oxygen metabolite; aging; caenorhabditis elegans; heat shock protein 70; protein folding; parkinson disease; mitochondrial protein; mitochondrion; oxidative phosphorylation; cell organelle; cytosol; biogenesis; cell stress; mitochondrial dna; presenilin; chaperone; disorders of mitochondrial functions; protein aggregation; outer membrane; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); unfolded protein response; parkin; pdz protein; serine proteinase omi; electron transport; protein quality |
| Journal Title: | Trends in Biochemical Sciences |
| Volume: | 36 |
| Issue: | 5 |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-05-01 |
| Start Page: | 254 |
| End Page: | 261 |
| Language: | English |
| DOI: | 10.1016/j.tibs.2011.01.004 |
| PROVIDER: | scopus |
| PUBMED: | 21353780 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: TBSCD" - "Source: Scopus" |
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