RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway Journal Article
| Authors: | Alonso Curbelo, D.; Riveiro-Falkenbach, E.; Pérez-Guijarro, E.; Cifdaloz, M.; Karras, P.; Osterloh, L.; Megías, D.; Cañón, E.; Calvo, T.; Olmeda, D.; Gómez-López, G.; Graña, O.; Sánchez-ArévaloLobo, V.; Pisano, D.; Wang, H. W.; Ortiz-Romero, P.; Tormo, D.; Hoek, K.; Rodríguez-Peralto, J.; Joyce, J.; Soengas, M. |
| Article Title: | RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway |
| Abstract: | Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells, clinical specimens, and mouse models demonstrated that RAB7 is an early-induced melanoma driver whose levels can be tuned to favor tumor invasion, ultimately defining metastatic risk. Importantly, RAB7 levels and function were independent of MITF, the best-characterized melanocyte lineage-specific transcription factor. Instead, we describe the neuroectodermal master modulator SOX10 and the oncogene MYC as RAB7 regulators. These results reveal a unique wiring of the lysosomal pathway that melanomas exploit to foster tumor progression. © 2014 Elsevier Inc. |
| Journal Title: | Cancer Cell |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2014-07-14 |
| Start Page: | 61 |
| End Page: | 76 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2014.04.030 |
| PROVIDER: | scopus |
| PUBMED: | 24981740 |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- CODEN: CCAEC -- Source: Scopus |
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