The knockout mouse project Journal Article
| Authors: | Austin, C. P.; Battey, J. F.; Bradley, A.; Bucan, M.; Capecchi, M.; Collins, F. S.; Dove, W. F.; Duyk, G.; Dymecki, S.; Eppig, J. T.; Grieder, F. B.; Heintz, N.; Hicks, G.; Insel, T. R.; Joyner, A.; Koller, B. H.; Lloyd, K. C. K.; Magnuson, T.; Moore, M. W.; Nagy, A.; Pollock, J. D.; Roses, A. D.; Sands, A. T.; Seed, B.; Skarnes, W. C.; Snoddy, J.; Soriano, P.; Stewart, D. J.; Stewart, F.; Stillman, B.; Varmus, H.; Varticovski, L.; Verma, I. M.; Vogt, T. F.; Von Melchner, H.; Witkowski, J.; Woychik, R. P.; Wurst, W.; Yancopoulos, G. D.; Young, S. G.; Zambrowicz, B. |
| Article Title: | The knockout mouse project |
| Abstract: | Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain. © 2004 Nature Publishing Group. |
| Keywords: | gene sequence; nonhuman; note; phenotype; embryonic stem cell; gene function; reporter gene; transcriptome; knockout mouse; harness; priority journal |
| Journal Title: | Nature Genetics |
| Volume: | 36 |
| Issue: | 9 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-09-01 |
| Start Page: | 921 |
| End Page: | 924 |
| Language: | English |
| DOI: | 10.1038/ng0904-921 |
| PROVIDER: | scopus |
| PMCID: | PMC2716027 |
| PUBMED: | 15340423 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):329 -- Export Date: 16 June 2014 -- CODEN: NGENE -- Source: Scopus |
