Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer Journal Article
| Authors: | Amankwah, E. K.; Kelemen, L. E.; Wang, Q.; Song, H.; Chenevix-Trench, G.; on behalf of the Australian Ovarian Cancer Study Group; Beesley, J.; Webb, P. M.; on behalf of the Australian Cancer Study (Ovarian Cancer); Pearce, C. L.; Wu, A. H.; Pike, M. C.; Stram, D. O.; Chang-Claude, J.; Wang-Gohrke, S.; Ness, R. B.; Goode, E. L.; Cunningham, J. M.; Fridley, B. L.; Vierkant, R. A.; Tworoger, S. S.; Whittemore, A. S.; McGuire, V.; Sieh, W.; Gayther, S. A.; Gentry-Maharaj, A.; Menon, U.; Ramus, S. J.; Rossing, M. A.; Doherty, J. A.; Goodman, M. T.; Carney, M. E.; Lurie, G.; Wilkens, L. R.; Kjær, S. K.; Høgdall, E.; Cramer, D. W.; Terry, K. L.; Garcia-Closas, M.; Yang, H.; Lissowska, J.; Anton-Culver, H.; Ziogas, A.; Schildkraut, J. M.; Berchuck, A.; Pharoah, P. D. P.; on behalf of the Ovarian Cancer Association Consortium |
| Article Title: | Prostate cancer susceptibility polymorphism rs2660753 s not associated with invasive ovarian cancer |
| Abstract: | Background: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI= 1.0-1.4, Ptrend = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, Ptrend = 0.003). Methods: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, Ptrend = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, Ptrend = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, Ptrend = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations. ©2011 AACR. |
| Keywords: | adult; controlled study; aged; major clinical study; histopathology; cancer susceptibility; ovary cancer; genotype; prostate cancer; cancer invasion; genetic risk; european american; correlational study; dna polymorphism |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 20 |
| Issue: | 5 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2011-05-01 |
| Start Page: | 1028 |
| End Page: | 1031 |
| Language: | English |
| DOI: | 10.1158/1055-9965.epi-11-0053 |
| PROVIDER: | scopus |
| PMCID: | PMC3176661 |
| PUBMED: | 21415361 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: CEBPE" - "Source: Scopus" |
