Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis Journal Article
| Authors: | Gaudet, M. M.; Hunter, K.; Pharoah, P.; Dunning, A. M.; Driver, K.; Lissowska, J.; Sherman, M.; Peplonska, B.; Brinton, L. A.; Chanock, S.; Garcia-Closas, M. |
| Article Title: | Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis |
| Abstract: | Genetic variation in SIPA1, signal-induced proliferation-associated gene 1, has been proposed to be associated with aggressive breast tumor characteristics related to metastasis and worse prognosis in humans and rodents. To test this hypothesis, we genotyped 3 single nucleotide polymorphisms (SNP) located at -3092 (A<G, rs931127), exon 3-135 (C>T, rs3741378), and exon 14 1 14 (C>T, rs746429), and examined them in relation to breast cancer risk and overall survival, stratified by tumor characteristics in 2 independent case-control studies conducted in Poland (1,995 cases, 2,296 controls) and in Britain (2,142 cases, 2,257 controls). Vital status (n = 396 deaths) was available for 911 Polish and 1,919 British breast cancer cases with an average follow-up time of 5.5 years. Overall, we found no significant associations between genetic variants of SIPA1 SNPs and breast cancer risk (per allele odds ratios, 95% confidence intervals (CI): rs931127-0.99, 0.931.06; rs3741378-1.03, 0.94-1.13; and, rs74642-0.98, 0.92-1.04). In both studies, SIPA1 polymorphisms were not related to overall mortality (per allele hazard ratios, 95% CI: 1.02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival. © 2008 Wiley-Liss, Inc. |
| Keywords: | cancer survival; controlled study; major clinical study; overall survival; single nucleotide polymorphism; case control study; exon; genetics; case-control studies; polymorphism, single nucleotide; mortality; cancer risk; follow up; allele; gene; tumor localization; genetic predisposition to disease; metastasis; breast cancer; tumor volume; nuclear protein; genetic variability; genotype; genetic variation; risk factors; breast neoplasms; risk factor; cancer mortality; nuclear proteins; kaplan-meiers estimate; disease severity; control group; breast tumor; guanosine triphosphatase activating protein; gtpase-activating proteins; kaplan meier method; genetic predisposition; poland; signal induced proliferation associated gene 1; tumor classification; united kingdom; vital statistics; sipa1 protein, human |
| Journal Title: | International Journal of Cancer |
| Volume: | 124 |
| Issue: | 7 |
| ISSN: | 0020-7136 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2009-04-01 |
| Start Page: | 1716 |
| End Page: | 1720 |
| Language: | English |
| DOI: | 10.1002/ijc.23919 |
| PUBMED: | 19089925 |
| PROVIDER: | scopus |
| PMCID: | PMC2914460 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: IJCNA" - "Source: Scopus" |
