Predicting survival of patients with metastatic renal cell carcinoma Journal Article


Authors: Motzer, R. J.; Mazumdar, M.
Article Title: Predicting survival of patients with metastatic renal cell carcinoma
Abstract: The relationship between pretreatment clinical features and survival was studied from patients treated on clinical trials for metastatic renal cell carcinoma (RCC) at the Memorial Sloan-Kettering Cancer Center. The primary analysis was performed on 670 patients treated with cytokines or chemotherapy, from which a multivariate model was derived to predict survival. Studies which followed addressed: (1) the survival of patients given interferon-α as first-line therapy; (2) a comparison of survival for patients treated with chemotherapy versus cytokine therapy; and (3) survival of patients with non-clear cell histology. Prospective identification of patients more likely to benefit from cytokine therapy is important as a stratification factor in phase III trials, and in risk-directed therapy.
Keywords: cancer chemotherapy; cancer survival; treatment outcome; disease-free survival; clinical feature; clinical trial; antineoplastic agents; clinical trials as topic; conference paper; alpha interferon; antineoplastic agent; interleukin 2; cancer immunotherapy; antineoplastic combined chemotherapy protocols; prediction; kidney carcinoma; kidney neoplasms; risk assessment; survival time; carcinoma, renal cell; neoplasm metastasis; long term care; multivariate analysis; high risk population; immunologic factors; kidney metastasis; interleukin-2; interferon-alpha; humans; prognosis; human
Journal Title: Der Urologe A
Volume: 43
Issue: Suppl.2
ISSN: 0340-2592
Publisher: Springer Verlag  
Date Published: 2004-09-01
Start Page: S135
End Page: S136
Language: English
DOI: 10.1007/s00120-004-0602-x
PROVIDER: scopus
PUBMED: 15148574
DOI/URL:
Notes: Urologe Ausg. A -- Cited By (since 1996):6 -- Export Date: 16 June 2014 -- CODEN: URGAB -- Source: Scopus
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MSK Authors
  1. Robert Motzer
    772 Motzer
  2. Madhu Mazumdar
    126 Mazumdar