The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder Journal Article
| Authors: | Sfakianos, J. P.; Gellert, L. L.; Maschino, A.; Gotto, G. T.; Kim, P. H.; Al-Ahmadie, H.; Bochner, B. H. |
| Article Title: | The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder |
| Abstract: | Objectives: The PI3k/Akt pathway has been associated with the development and progression of bladder tumors, with most studies focused on papillary or muscle-invasive tumors. We sought to characterize the expression patterns of the PI3K/Akt pathway in a large cohort of high-risk preinvasive carcinoma in situ (CIS) tumors of the bladder. Our goal was to understand whether PI3K/Akt pathway alterations associated with CIS resemble early- or late-stage bladder cancers. Material and methods: We evaluated tissue specimens from 97 patients with CIS of the bladder, of which 14 had a concomitant papillary tumor. All patients were treated with intravesical bacillus Calmette-Guerin. All specimens were evaluated for PTEN, p-AKT, and p-S6 immunoreactivity. Markers were evaluated for percentage and intensity of staining and were scored using a 0 to 3+grading system. Results: PTEN staining was noted as least intense in 67% of tumor specimens and 22% of normal urothelium. P-Akt and p-S6 had intense staining in 77% and 90% of tumor specimens vs. 44% and 68% in normal tissue, respectively. Low-intensity staining for PTEN at 12 months correlated with higher recurrence risk (P = 0.026). Conclusion: We describe a large cohort of CIS bladder tumors with decreased staining intensity of PTEN and increased staining intensity of p-AKT and p-S6, similar to high-grade and high-stage papillary tumors. Low-intensity staining of PTEN at 12 months was associated with an increased risk of recurrence. © 2014 Elsevier Inc. |
| Keywords: | bladder cancer; carcinoma in situ; pten |
| Journal Title: | Urologic Oncology: Seminars and Original Investigations |
| Volume: | 32 |
| Issue: | 5 |
| ISSN: | 1078-1439 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-07-01 |
| Start Page: | 657 |
| End Page: | 662 |
| Language: | English |
| DOI: | 10.1016/j.urolonc.2014.02.003 |
| PROVIDER: | scopus |
| PMCID: | PMC4062573 |
| PUBMED: | 24840867 |
| DOI/URL: | |
| Notes: | Urol. Oncol. Semin. Orig. Invest. -- Export Date: 8 July 2014 -- CODEN: UOSOA -- Source: Scopus |
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