MicroRNA-related cofilin abnormality in Alzheimer's disease Journal Article
| Authors: | Yao, J.; Hennessey, T.; Flynt, A.; Lai, E.; Flint Beal, M.; Lin, M. T. |
| Article Title: | MicroRNA-related cofilin abnormality in Alzheimer's disease |
| Abstract: | Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR- 107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD. © 2010 Yao et al. |
| Keywords: | controlled study; unclassified drug; nonhuman; protein analysis; animal cell; mouse; animal tissue; microrna; embryo; animal experiment; animal model; nucleotide sequence; rna translation; cell level; alzheimer disease; rna sequence; brain level; protein aggregation; brain nerve cell; cofilin; microrna 103; microrna 107; translation regulation |
| Journal Title: | PLoS ONE |
| Volume: | 5 |
| Issue: | 12 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2010-12-16 |
| Start Page: | e15546 |
| Language: | English |
| DOI: | 10.1371/journal.pone.0015546 |
| PROVIDER: | scopus |
| PMCID: | PMC3002958 |
| PUBMED: | 21179570 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Art. No.: e15546" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work