Ibrutinib resistance in chronic lymphocytic leukemia Journal Article
| Authors: | Furman, R. R.; Cheng, S.; Lu, P.; Setty, M.; Perez, A. R.; Guo, A.; Racchumi, J.; Xu, G.; Wu, H.; Ma, J.; Steggerda, S. M.; Coleman, M.; Leslie, C.; Wang, Y. L. |
| Article Title: | Ibrutinib resistance in chronic lymphocytic leukemia |
| Keywords: | adult; middle aged; treatment failure; mutation; disease course; case report; letter; polymerase chain reaction; allele; computer assisted tomography; amino acid substitution; serine; relapse; recurrence; drug resistance, neoplasm; enzyme activity; pyrimidines; phosphorylation; drug dose escalation; enzyme phosphorylation; blood sampling; pyrazoles; nucleotide sequence; drug response; protein-tyrosine kinases; point mutation; chronic lymphatic leukemia; lymphadenopathy; drug protein binding; leukemia, lymphocytic, chronic, b-cell; genomic dna; lymphocyte count; cysteine; electrophoresis; complementary dna; thymidine; rna sequence; enzyme active site; sequence analysis, dna; adenine; receptors, antigen, b-cell; covalent bond; drug concentration; thiol derivative; bruton tyrosine kinase; ibrutinib; humans; human; female; priority journal; maximal inhibitory concentration |
| Journal Title: | New England Journal of Medicine |
| Volume: | 370 |
| Issue: | 24 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 2014-06-12 |
| Start Page: | 2352 |
| End Page: | 2354 |
| Language: | English |
| DOI: | 10.1056/NEJMc1402716 |
| PROVIDER: | scopus |
| PUBMED: | 24869597 |
| PMCID: | PMC4512173 |
| DOI/URL: | |
| Notes: | New Engl. J. Med. -- Cited By (since 1996):1 -- Export Date: 8 July 2014 -- CODEN: NEJMA -- Molecular Sequence Numbers: GENBANK: NM_000061; -- Source: Scopus |
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