Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages Journal Article
| Authors: | Cavnar, M. J.; DeMatteo, R. P. |
| Article Title: | Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages |
| Abstract: | In gastrointestinal stromal tumor (GIST ), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status. ©2014 Landes Bioscience. |
| Keywords: | gastrointestinal stromal tumor; macrophage; tumor-associated macrophage; c/ebpβ; csf1r |
| Journal Title: | OncoImmunology |
| Volume: | 3 |
| Issue: | 4 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2014-04-17 |
| Start Page: | e28463-1 |
| End Page: | e28463-3 |
| Language: | English |
| DOI: | 10.4161/onci.28463 |
| PROVIDER: | scopus |
| PMCID: | PMC4063150 |
| PUBMED: | 25050212 |
| DOI/URL: | |
| Notes: | OncoImmunology -- Export Date: 8 July 2014 -- Source: Scopus |
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