Benign and malignant spindle cell lesions of the breast Journal Article
| Author: | Brogi, E. |
| Article Title: | Benign and malignant spindle cell lesions of the breast |
| Abstract: | Spindle cell lesions of the breast constitute a wide spectrum of benign and malignant proliferations. Myofibroblasts, normal cellular constituents of the mammary intra- and interlobular stroma, compose many of these lesions, which include reactive proliferations and benign or locally aggressive neoplasms. Because of its morphology, low-grade metaplastic spindle cell carcinoma, "fibromatosis-like" is also considered together with spindle cell lesions of the breast. Although certain of the lesions do not occur commonly, they represent diagnostic challenges. This review outlines the morphology of certain spindle cell lesions of the breast including pseudoangiomatous stromal hyperplasia, reactive spindle cell nodule, nodular fasciitis, myofibroblastoma, primary mammary fibromatosis, and low-grade metaplastic spindle cell carcinoma, "fibromatosis-like." The differential diagnosis and diagnostic work-up of these lesions is discussed, and their clinical treatment and prognosis briefly summarized. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | metaplasia; review; cancer grading; diagnosis, differential; differential diagnosis; breast neoplasms; breast tumor; hyperplasia; carcinoma; diagnostic error; stroma; spindle cell; fibroma; myofibroblast; diagnostic test; spindle cell carcinoma; stromal cells; breast lesion; neoplasms, muscle tissue; metaplastic spindle cell carcinoma; myofibroblastoma; fasciitis; humans; prognosis; human; priority journal; "fibromatosis-like"; nodular fasciitis; primary mammary fibromatosis; pseudoangiomatous stromal hyperplasia; reactive spindle cell nodule; breast spindle cell lesion; reactive spindle nodule |
| Journal Title: | Seminars in Diagnostic Pathology |
| Volume: | 21 |
| Issue: | 1 |
| ISSN: | 0740-2570 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-02-01 |
| Start Page: | 57 |
| End Page: | 64 |
| Language: | English |
| DOI: | 10.1053/j.semdp.2003.10.007 |
| PROVIDER: | scopus |
| PUBMED: | 15074560 |
| DOI/URL: | |
| Notes: | Semin. Diagn. Pathol. -- Cited By (since 1996):16 -- Export Date: 16 June 2014 -- CODEN: SDPAE -- Source: Scopus |
