The mechanism of the anti-tumor activity of the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) Journal Article
| Author: | Marks, P. A. |
| Article Title: | The mechanism of the anti-tumor activity of the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) |
| Abstract: | Histone deacetylases (HDAC) are ubiquitously distributed through chromatin. Nevertheless HDAC inhibitors (HDACi), such as SAHA, selectively alter the transcription of as few as 2-5% of expressed genes in various transformed cells. p21WAF1 is one of the most commonly induced genes in cells cultured with SAHA. Understanding the mechanism of the selective effects of the HDACi is a challenging problem. Gui et al. have identified effects of SAHA on p21 WAF1 promotor associated proteins that explain, at least in part, the selective effects of HDAC in altering gene expression. |
| Keywords: | human cell; promoter region; genetics; histone deacetylase inhibitor; review; nonhuman; antineoplastic agents; antineoplastic agent; animal cell; metabolism; gene; gene expression; genetic transcription; transcription, genetic; antineoplastic activity; drug effect; enzyme inhibitor; cell line, tumor; gene expression regulation; drug antagonism; drug mechanism; cell culture; enzyme inhibitors; cell transformation; chromatin; tumor cell line; vorinostat; hydroxamic acids; gene induction; cyclin dependent kinase inhibitor 1a; cyclin-dependent kinase inhibitor p21; cycline; cyclins; histones; histone deacetylases; hydroxamic acid; histone deacetylase; cdkn1a protein, human; suberoylanilide hydroxamic acid; promoter regions (genetics); humans; human; article; p21waf1 gene; p21 waf1 gene |
| Journal Title: | Cell Cycle |
| Volume: | 3 |
| Issue: | 5 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2004-05-01 |
| Start Page: | 534 |
| End Page: | 535 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15020838 |
| DOI: | 10.4161/cc.3.5.824 |
| DOI/URL: | |
| Notes: | Export Date: 16 June 2014 -- Source: Scopus |
