MUC1 and MUC2 in pancreatic neoplasia Journal Article
| Authors: | Levi, E.; Klimstra, D. S.; Adsay, N. V.; Andea, A.; Basturk, O. |
| Article Title: | MUC1 and MUC2 in pancreatic neoplasia |
| Abstract: | MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other actions, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. In contrast, MUC2 is normally found only in goblet cells, where it contributes to the protective barrier function of these cells. Recently, a tumour suppressor role has been demonstrated for MUC2, and both MUC1 and MUC2 appear to have important roles in pancreatic neoplasia. MUC1 appears to be a marker of aggressive phenotype and may facilitate the vascular spread of carcinoma cells. In contrast, MUC2 is rarely detectable in aggressive pancreatic tumours, but is commonly expressed in intraductal papillary mucinous neoplasms (IPMNs), which are rare, indolent tumours, in intestinal IPMNs, and in indolent colloid carcinomas. MUC2 appears to be not only a marker of this indolent pathway, but also partly responsible for its less aggressive nature. Thus, in pancreatic neoplasia, MUC1 and MUC2 have potential diagnostic and prognostic value as markers of aggressive and indolent phenotypes, respectively, and have potential as therapeutic targets. |
| Keywords: | signal transduction; protein expression; disease course; review; cancer patient; pancreatic neoplasms; binding affinity; protein domain; protein function; phenotype; cell function; neoplasm proteins; protein binding; prediction; morphology; carcinogenesis; cell transformation, neoplastic; pancreas carcinoma; cancer invasion; cancer inhibition; correlation analysis; pancreas tumor; peptide fragments; staining; stroma; inhibition kinetics; neoplasm invasiveness; mucin 1; epithelium; molecular biology; protein structure; homeostasis; structure analysis; colloid carcinoma; intestine tumor; cell interaction; cell protection; glycoprotein; carcinoma cell; protein polymerization; goblet cell; mucins; mucin 2; marker; ca-15-3 antigen; humans; prognosis; human; priority journal |
| Journal Title: | Journal of Clinical Pathology |
| Volume: | 57 |
| Issue: | 5 |
| ISSN: | 0021-9746 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 2004-05-01 |
| Start Page: | 456 |
| End Page: | 462 |
| Language: | English |
| DOI: | 10.1136/jcp.2003.013292 |
| PROVIDER: | scopus |
| PMCID: | PMC1770304 |
| PUBMED: | 15113850 |
| DOI/URL: | |
| Notes: | J. Clin. Pathol. -- Cited By (since 1996):67 -- Export Date: 16 June 2014 -- CODEN: JCPAA -- Source: Scopus |
