Aromatase inhibitors for hormonal therapy of early-stage breast cancer Journal Article
| Authors: | Traina, T. A.; Dickler, M. N. |
| Article Title: | Aromatase inhibitors for hormonal therapy of early-stage breast cancer |
| Abstract: | Aromatase inhibitors block estrogen synthesis by inhibiting aromatase, the enzyme responsible for the conversion of adrenal steroids to estrogen. They are approved for the first-line treatment of metastatic breast cancer in hormone receptor-positive women. Three large, well-designed randomized trials have been reported which support the use of aromatase inhibitors in the treatment of early stage breast cancer. This review focuses on data on aromatase inhibitors in the adjuvant setting and looks to the future potential of these drugs in both ductal carcinoma in situ and chemoprevention. © The Thomson Corporation ISSN 1472-4472. |
| Keywords: | clinical trial; review; metabolism; controlled clinical trial; breast cancer; classification; randomized controlled trial; aromatase inhibitor; enzymology; enzyme inhibitor; breast neoplasms; chemistry; randomized controlled trials; enzyme inhibitors; breast tumor; antineoplastic agents, hormonal; drugs, investigational; aromatase inhibitors; antineoplastic hormone agonists and antagonists; hormone therapy; aromatase; adjuvant; new drug; humans; human; female |
| Journal Title: | Current Opinion in Investigational Drugs |
| Volume: | 5 |
| Issue: | 6 |
| ISSN: | 1472-4472 |
| Publisher: | Current Drugs Ltd |
| Date Published: | 2004-06-01 |
| Start Page: | 605 |
| End Page: | 610 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15242248 |
| DOI/URL: | |
| Notes: | Curr. Opin. Invest. Drugs -- Export Date: 16 June 2014 -- CODEN: CIDRE C2 - 15242248 -- Source: Scopus |
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