Relevance of external beam dose-response relationships to kidney toxicity associated with radionuclide therapy Journal Article
| Authors: | O'Donoghue, J. |
| Article Title: | Relevance of external beam dose-response relationships to kidney toxicity associated with radionuclide therapy |
| Abstract: | The importance of the kidney as a dose-limiting organ is likely to increase as smaller molecular vectors and radiometals become more commonly used in targeted radionuclide therapy. Data derived from kidney irradiation by external-beam therapy (XRT) indicate that the kidney is radiosensitive. The features of radiation nephropathy seen post-treatment appear similar between local XRT, total-body irradiation (TBI), and radionuclide therapy. For uniform kidney irradiation, tolerance doses appear to be approximately 15-17 Gy in 2 Gy fractions for local XRT and probably less than this (∼12 Gy in 2 Gy fractions) when radiation is delivered systemically as TBI in the context of bone marrow transplant protocols. Animal studies indicate that the linear quadratic (LQ) model with an α/β parameter of 1.5-3 Gy seems to adequately describe the XRT fractionation sensitivity of kidney for doses per fraction down to approximately 1 Gy, but may underestimate the effectiveness of fraction sizes less than this. Animal studies have also clarified the dose-dependency of the time to expression of radiation nephropathy and have indicated that radiation nephropathy may be alleviated by pharmacological means. |
| Keywords: | review; dose response; nonhuman; cancer radiotherapy; radiation dose; positron emission tomography; animals; nephrotoxicity; animal model; radiation injury; time factors; dose-response relationship, radiation; whole body radiation; kidney; kidney function; dosimetry; radiopharmaceutical agent; radiosensitivity; fractionation; bone marrow transplantation; single photon emission computer tomography; radioisotopes; statistical model; angiotensin 2 receptor antagonist; captopril; dipeptidyl carboxypeptidase inhibitor; drug tolerance; animal models; radiation tolerance; dose-response; external beam; beam therapy; kidney diseases; radiation nephropathy; humans; priority journal |
| Journal Title: | Cancer Biotherapy and Radiopharmaceuticals |
| Volume: | 19 |
| Issue: | 3 |
| ISSN: | 1084-9785 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 2004-06-01 |
| Start Page: | 378 |
| End Page: | 387 |
| Language: | English |
| DOI: | 10.1089/1084978041425025 |
| PROVIDER: | scopus |
| PUBMED: | 15285886 |
| DOI/URL: | |
| Notes: | Cancer Biother. Radiopharm. -- Cited By (since 1996):29 -- Export Date: 16 June 2014 -- CODEN: CBRAF -- Source: Scopus |
