Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells Journal Article
| Authors: | Nimer, S. D.; Moore, M. A. S. |
| Article Title: | Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells |
| Abstract: | Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed. |
| Keywords: | signal transduction; protein expression; leukemia; unclassified drug; oncoprotein; acute granulocytic leukemia; genetics; review; nonhuman; metabolism; gene expression profiling; protein protein interaction; gene locus; transcription factor; cell differentiation; cell lineage; transcription factors; hybrid protein; messenger rna; rna, messenger; cell transformation; leukemogenesis; oncogene proteins, fusion; progeny; transgene; hematopoietic stem cells; murinae; gene control; immunophenotyping; hematopoietic stem cell; core binding factor alpha 2 subunit; transcription factor gata 1; leukemia remission; gene construct; transcription factor runx1; aml; down syndrome; aml1-eto; chromosome translocation 8; stem cell biology; aml1 eto fusion protein, human; aml1-eto fusion protein, human; humans; human; priority journal; transcription factor runx 1 |
| Journal Title: | Oncogene |
| Volume: | 23 |
| Issue: | 24 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-05-24 |
| Start Page: | 4249 |
| End Page: | 4254 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1207673 |
| PROVIDER: | scopus |
| PUBMED: | 15156180 |
| DOI/URL: | |
| Notes: | Oncogene -- Cited By (since 1996):30 -- Export Date: 16 June 2014 -- CODEN: ONCNE -- Source: Scopus |
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