Genetic methods for illuminating the function of neural circuits Journal Article


Author: Miesenboeck, G.
Article Title: Genetic methods for illuminating the function of neural circuits
Abstract: Guided by the notion that biology itself offers some of the most incisive tools for studying biological systems, neurophysiologists rely increasingly on cell biological mechanisms and materials encoded in DNA to visualize and control the activity of neurons in functional circuits. Optical reporter proteins can broadcast the operational states of genetically designated cells and synapses; remote-controlled effectors can suppress or induce electrical activity. Many challenges, however, remain. These include the development of novel gene expression systems that target reporters and effectors to functionally relevant neuronal ensembles, the capacity to monitor and manipulate multiple populations of neurons in parallel, the ability to observe and elicit precisely timed action potentials, and the power to communicate with genetically designated target neurons through electromagnetic signals other than light.
Keywords: signal transduction; review; nonhuman; genetic analysis; animals; gfp; green fluorescent protein; molecular dynamics; gene function; neurons; cell population; central nervous system; genes, reporter; molecular biology; genetic code; electric activity; magnetics; neural pathways; neuropsychology; synaptic transmission; action potentials; humans; priority journal; nerve excitability
Journal Title: Current Opinion in Neurobiology
Volume: 14
Issue: 3
ISSN: 0959-4388
Publisher: Elsevier Inc.  
Date Published: 2004-06-01
Start Page: 395
End Page: 402
Language: English
DOI: 10.1016/j.conb.2004.05.004
PROVIDER: scopus
PUBMED: 15194122
DOI/URL:
Notes: Curr. Opin. Neurobiol. -- Cited By (since 1996):42 -- Export Date: 16 June 2014 -- CODEN: COPUE -- Source: Scopus
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