Where the crossovers are: Recombination distributions in mammals Journal Article
| Authors: | Kauppi, L.; Jeffreys, A. J.; Keeney, S. |
| Article Title: | Where the crossovers are: Recombination distributions in mammals |
| Abstract: | Until recently, recombination studies in humans and mice had identified only a few anecdotal examples of crossover hot spots. Recently, the pace of discovery has accelerated. In every genomic segment that has been examined at sufficiently high resolution, recombination events have a punctate recombination distribution: they are clustered within small (1-2-kb) regions that are surrounded by large stretches of recombinationally suppressed DNA. Here, we review progress in understanding the distribution of mammalian recombination events, tie mammalian results together with informative studies in budding yeast and discuss the consequences of these findings for genome diversity and evolution. |
| Keywords: | single nucleotide polymorphism; genetics; polymorphism, single nucleotide; review; nonhuman; mouse; animal; meiosis; mammalia; animals; gene; genetic variability; linkage disequilibrium; evolution; dna; genetic recombination; mammal; genomics; yeast; saccharomycetales; genes, mhc class ii; mammals; chromosome map; chromosome mapping; crossing over; crossing over, genetic; gene linkage disequilibrium; saccharomyces; variation (genetics); human; priority journal |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 5 |
| Issue: | 6 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-06-01 |
| Start Page: | 413 |
| End Page: | 424 |
| Language: | English |
| DOI: | 10.1038/nrg1346 |
| PROVIDER: | scopus |
| PUBMED: | 15153994 |
| DOI/URL: | |
| Notes: | Nat. Rev. Gen. -- Cited By (since 1996):156 -- Export Date: 16 June 2014 -- CODEN: NRGAA -- Source: Scopus |
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