Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors Journal Article

  


Authors: Wood, L. S.; Lemont, H.; Jatoi, A.; Lacouture, M. E.; Robert, C.; Keating, K.; Anderson, R.
Article Title: Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors
Abstract: Multikinase inhibitors (MKIs, eg, sorafenib and sunitinib) are oral anticancer agents associated with handfoot skin reaction (HFSR), a cutaneous adverse event affecting 20%-40% of patients treated with these drugs. Although usually mild, symptoms of HFSR can evolve into a painful condition, resulting in a shortened duration or intensity of cancer treatment. An international, interdisciplinary panel of experts recently provided the first consensus recommendations for the management of MKI-associated HFSR. © 2010 Elsevier Inc. All rights reserved.
Keywords: cancer chemotherapy; debridement; unclassified drug; clinical feature; clinical trial; disease course; sorafenib; bevacizumab; doxorubicin; fluorouracil; sunitinib; treatment duration; hand foot skin reaction; skin manifestation; capecitabine; cancer patient; disease association; peripheral neuropathy; hyperkeratosis; drug hypersensitivity; disease severity; prophylaxis; cediranib; pazopanib; erythema; rating scale; daily life activity; emollient agent; dermatitis; lidocaine; axitinib; disease control; hand foot syndrome; hypersensitivity reaction; analgesic agent; pyoderma gangrenosum; lactic acid; self care; fluocinonide; tazarotene; urea; blister; salicylic acid; skin edema; skin pain; votrient; skin abrasion; 2 hydroxyacid; cerave; clobetasol propionate; glycolic acid; keratolytic agent; lanolin alcohol; petrolatum; pumice; callus; cream; metatarsal bone
Journal Title: Community Oncology
Volume: 7
Issue: 1
ISSN: 1548-5315
Publisher: Elsevier Inc.  
Date Published: 2010-01-01
Start Page: 23
End Page: 29
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77649213517&partnerID=40&md5=d72706b64ee0e9120daca236c8fe8bea
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "Source: Scopus"